MM-102 TFA( HMTase Inhibitor IX TFA )

Catalog No. M22741 CAS No. 1883545-52-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MM-102 TFA
Note

Research use only, not for human use.
Brief Description

MM-102 TFA is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM.?MM-102 compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WDR5) and results in the inhibition of MLL1 H3K4 histone methyltransferase (HMT) activity.
Description

MM-102 TFA is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM.?MM-102 compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WDR5) and results in the inhibition of MLL1 H3K4 histone methyltransferase (HMT) activity.?Down-Regulation of H3K4me3 by MM-102 Facilitates Epigenetic Reprogramming of Porcine Somatic Cell Nuclear Transfer EmbryMM-102, in bone marrow cells transduced with MLL1-AF9 fusion construct shows that the compound effectively decreases the expression of HoxA9 and Meis-1, two critical MLL1 target genes in MLL1 fusion protein mediated leukemogenesis.?MM-102 also specifically inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins.?
In Vitro

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In Vivo

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Synonyms

HMTase Inhibitor IX TFA
Pathway

Others
Target

Other Targets
Recptor

MLL1
Research Area

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Indication

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CAS Number

1883545-52-5
Formula Weight

783.83
Molecular Formula

C37H50F5N7O6
Purity

>98% (HPLC)
Solubility

DMSO:99 mg/mL(126.3 mM)
SMILES

OC(=O)C(F)(F)F.CCC(CC)(NC(=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1(CCCC1)C(=O)NC(c1ccc(F)cc1)c1ccc(F)cc1
Chemical Name

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1. Karatas H, et al. J Am Chem Soc. 2013, 135(2), 669-682.

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