MM-102 TFA ( HMTase Inhibitor IX TFA )

Catalog No. M22741 CAS No. 1883545-52-5

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Datasheet

HNMR

HPLC

MSDS

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Product Name

MM-102 TFA
Note

Research use only, not for human use.
Brief Description

MM-102 TFA is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM.?MM-102 compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WDR5) and results in the inhibition of MLL1 H3K4 histone methyltransferase (HMT) activity.
Description

MM-102 TFA is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM.?MM-102 compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WDR5) and results in the inhibition of MLL1 H3K4 histone methyltransferase (HMT) activity.?Down-Regulation of H3K4me3 by MM-102 Facilitates Epigenetic Reprogramming of Porcine Somatic Cell Nuclear Transfer EmbryMM-102, in bone marrow cells transduced with MLL1-AF9 fusion construct shows that the compound effectively decreases the expression of HoxA9 and Meis-1, two critical MLL1 target genes in MLL1 fusion protein mediated leukemogenesis.?MM-102 also specifically inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins.?
Synonyms

HMTase Inhibitor IX TFA
Pathway

Others
Target

Other Targets
Recptor

MLL1
Research Area

——
Indication

——

CAS Number

1883545-52-5
Formula Weight

783.83
Molecular Formula

C37H50F5N7O6
Purity

>98% (HPLC)
Solubility

DMSO:99 mg/mL(126.3 mM)
SMILES

OC(=O)C(F)(F)F.CCC(CC)(NC(=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1(CCCC1)C(=O)NC(c1ccc(F)cc1)c1ccc(F)cc1
Chemical Name

——

1. Karatas H, et al. J Am Chem Soc. 2013, 135(2), 669-682.

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